Semaglutide 5 sizes RESEARCH USE ONLY BLACK BOX BIOTECHNOLOGY · SM5

Semaglutide

Also known as: GLP-1 receptor agonist · NN9535
Metabolic & GLP-1 In stock Box of 10 vials 1 reference

Long-acting GLP-1 receptor agonist — the reference compound for incretin-based metabolic research.

Available sizes

SKUPer vialPack
SM5 5 mg 10 vials / box
SM10 10 mg 10 vials / box
SM15 15 mg 10 vials / box
SM20 20 mg 10 vials / box
SM30 30 mg 10 vials / box

Order Semaglutide

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Semaglutide is a 31-amino-acid glucagon-like peptide-1 (GLP-1) analogue engineered with a C18 fatty-diacid side chain that binds albumin, extending its half-life to roughly one week. It activates the GLP-1 receptor, which is expressed in pancreatic islets, the gastrointestinal tract and hypothalamic appetite circuits.

In the 68-week STEP 1 trial (n = 1,961), once-weekly semaglutide 2.4 mg produced a mean body-weight change of −14.9% versus −2.4% with placebo in adults with overweight or obesity 1. It is among the most extensively characterised peptides in the metabolic literature and serves as the benchmark against which newer incretin compounds are compared.

At a glance

  • GLP-1 receptor agonist with ~1-week half-life (albumin-binding fatty-diacid side chain)
  • Phase 3 evidence base: STEP programme, SUSTAIN programme
  • Lyophilized; supplied in 5, 10, 15, 20 and 30 mg vials
Research use only. All products are sold strictly for laboratory research and development purposes. They are not intended for human or veterinary use, diagnosis, treatment, cure or prevention of any disease. Not for human consumption. Summaries above describe published findings in laboratory and clinical research models and do not constitute claims about this product.
Form
Lyophilized powder
Purity
HPLC-verified — Certificate of Analysis available on request
Pack size
Box of 10 vials
Storage
Lyophilized: −20 °C, protected from light (2–8 °C short-term). Reconstituted: 2–8 °C.
Sequence
H-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEAc-AEEAc-γ-Glu-C18-diacid)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH
Formula
C187H291N45O59
Mol. weight
4113.6 g/mol
CAS No.
910463-68-2

Sequence, formula and CAS data are provided for identification. Batch-specific purity, mass-spec and HPLC data are on the Certificate of Analysis — ask for it with your order.

  1. Wilding JPH, Batterham RL, Calanna S, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021;384(11):989-1002.

Citations retrieved from PubMed (NCBI). Links open the publisher record via DOI and the PubMed abstract.

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