Cognitive
Semax
Also known as: ACTH (4-7)-Pro-Gly-Pro · Met-Glu-His-Phe-Pro-Gly-Pro
Cognitive & Sleep In stock Box of 10 vials 2 references
Heptapeptide ACTH(4-7) analogue studied for neuroprotection and cognitive enhancement.
Available sizes
| SKU | Per vial | Pack | |
|---|---|---|---|
| XA5 | 5 mg | 10 vials / box | |
| XA10 | 10 mg | 10 vials / box | |
| XA30 | 30 mg | 10 vials / box |
Order Semax
Pricing is quoted directly and is competitive at every tier — message us with the SKUs you want and quantities for a quote.
Replies within 36 hours. Cryptocurrency (preferred) or card / money-app with a processing fee. COA for this batch available on request.
Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) consisting of the ACTH(4-7) fragment extended with the C-terminal tripeptide Pro-Gly-Pro, which confers metabolic stability. It has no hormonal (corticotropic) activity. Developed at the Institute of Molecular Genetics in Moscow, it is used clinically in Russia in ischaemic stroke.
Genome-wide transcriptional studies in rat focal cerebral ischaemia show Semax markedly alters expression of immune- and vascular-system genes, with over half of the affected genes relating to immune response — proposed as the basis of its neuroprotective action 12.
At a glance
- ACTH fragment analogue without corticotropic activity
- Studied in ischaemic stroke, cognition and BDNF regulation
- 5, 10 and 30 mg vials; also blended with Selank
Research use only. All products are sold strictly for laboratory research and development purposes. They are not intended for human or veterinary use, diagnosis, treatment, cure or prevention of any disease. Not for human consumption. Summaries above describe published findings in laboratory and clinical research models and do not constitute claims about this product.
- Form
- Lyophilized powder
- Purity
- HPLC-verified — Certificate of Analysis available on request
- Pack size
- Box of 10 vials
- Storage
- Lyophilized: −20 °C, protected from light (2–8 °C short-term). Reconstituted: 2–8 °C.
- Sequence
- Met-Glu-His-Phe-Pro-Gly-Pro
- Formula
- C37H51N9O10S
- Mol. weight
- 813.9 g/mol
- CAS No.
- 80714-61-0
Sequence, formula and CAS data are provided for identification. Batch-specific purity, mass-spec and HPLC data are on the Certificate of Analysis — ask for it with your order.
- Medvedeva EV, Dmitrieva VG, Povarova OV, et al. The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis. BMC Genomics. 2014;15:228.
- Medvedeva EV, Dmitrieva VG, Limborska SA, et al. Semax, an analog of ACTH, regulates expression of immune response genes during ischemic brain injury in rats. Mol Genet Genomics. 2017;292(3):635-653.
Citations retrieved from PubMed (NCBI). Links open the publisher record via DOI and the PubMed abstract.
Related
Often ordered together
Cognitive Blend
Semax + Selank
Nootropic blend
The two Moscow regulatory heptapeptides co-formulated 1:1.
20 mg (10 + 10)
Cognitive
Cognitive