Epithalon
Khavinson tetrapeptide reported to activate telomerase in human somatic cells.
Available sizes
| SKU | Per vial | Pack | |
|---|---|---|---|
| ET10 | 10 mg | 10 vials / box | |
| ET25 | 25 mg | 10 vials / box | |
| ET50 | 50 mg | 10 vials / box |
Order Epithalon
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Epithalon is the synthetic tetrapeptide Ala-Glu-Asp-Gly, designed from the pineal-gland extract epithalamin. It is the most studied of the Khavinson bioregulator peptides.
In human somatic-cell cultures, Epithalon induced telomerase activity and telomere elongation 1 and allowed cells to exceed the Hayflick division limit 2. Long-term clinical observations of epithalamin and thymalin in elderly patients reported reduced mortality and improved physiological markers 3.
At a glance
- Reported telomerase activation in human cell lines
- Pineal bioregulator; studied in circadian and aging models
- 10, 25 and 50 mg vials
- Form
- Lyophilized powder
- Purity
- HPLC-verified — Certificate of Analysis available on request
- Pack size
- Box of 10 vials
- Storage
- Lyophilized: −20 °C, protected from light (2–8 °C short-term). Reconstituted: 2–8 °C.
- Sequence
- Ala-Glu-Asp-Gly
- Formula
- C14H22N4O9
- Mol. weight
- 390.3 g/mol
- CAS No.
- 307297-39-8
Sequence, formula and CAS data are provided for identification. Batch-specific purity, mass-spec and HPLC data are on the Certificate of Analysis — ask for it with your order.
- Khavinson VKh, Bondarev IE, Butyugov AA Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003;135(6):590-2.
- Khavinson VKh, Bondarev IE, Butyugov AA, et al. Peptide promotes overcoming of the division limit in human somatic cell. Bull Exp Biol Med. 2004;137(5):503-6.
- Khavinson VKh, Morozov VG Peptides of pineal gland and thymus prolong human life. Neuro Endocrinol Lett. 2003;24(3-4):233-40.
Citations retrieved from PubMed (NCBI). Links open the publisher record via DOI and the PubMed abstract.