Metabolic
Adipotide
Also known as: FTPP · Prohibitin-targeting peptide
Metabolic & GLP-1 In stock Box of 10 vials 1 reference
Peptidomimetic that targets the vasculature of white adipose tissue.
Available sizes
| SKU | Per vial | Pack | |
|---|---|---|---|
| AP5 | 5 mg | 10 vials / box | |
| AP10 | 10 mg | 10 vials / box |
Order Adipotide
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Adipotide (FTPP) is a proapoptotic peptidomimetic consisting of a homing motif (CKGGRAKDC) that binds prohibitin on white-fat blood vessels, linked to the membrane-disrupting sequence D(KLAKLAK)2. Binding triggers apoptosis of the targeted endothelial cells, reducing blood supply to adipose tissue.
In obese rhesus monkeys, four weeks of adipotide produced rapid weight loss and improved insulin resistance; body weight and abdominal fat decreased and the effects persisted after treatment ended 1. Reversible renal effects were observed and are a key parameter in ongoing research.
At a glance
- Vascular-targeted apoptotic mechanism (prohibitin / D(KLAKLAK)2)
- Non-human primate data published in Science Translational Medicine
- 5 mg and 10 mg vials
Research use only. All products are sold strictly for laboratory research and development purposes. They are not intended for human or veterinary use, diagnosis, treatment, cure or prevention of any disease. Not for human consumption. Summaries above describe published findings in laboratory and clinical research models and do not constitute claims about this product.
- Form
- Lyophilized powder
- Purity
- HPLC-verified — Certificate of Analysis available on request
- Pack size
- Box of 10 vials
- Storage
- Lyophilized: −20 °C, protected from light (2–8 °C short-term). Reconstituted: 2–8 °C.
- Sequence
- CKGGRAKDC-GG-D(KLAKLAK)2
- Mol. weight
- 2611.3 g/mol
- CAS No.
- 859216-15-2
Sequence, formula and CAS data are provided for identification. Batch-specific purity, mass-spec and HPLC data are on the Certificate of Analysis — ask for it with your order.
- Barnhart KF, Christianson DR, Hanley PW, et al. A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys. Sci Transl Med. 2011;3(108):108ra112.
Citations retrieved from PubMed (NCBI). Links open the publisher record via DOI and the PubMed abstract.
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5-Amino-1MQ
5-amino-1-methylquinolinium · NNMT inhibitor
Small-molecule NNMT inhibitor studied in adipocyte and diet-induced obesity models.
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